![]() ![]() ![]() Phenotypic and genetic analyses of TF mutants enable the organization of these four TFs and PHO1 H3 in a new gene regulatory network controlling phosphate accumulation in zinc-dependent manner. These TFs were confirmed to interact between themselves and with the PHO1 H3 promoter. TransDetect was used to identify novel TF modules regulating the expression of Arabidopsis ( Arabidopsis thaliana) phosphate transporter PHO1 H3 comprising MYB15, MYB84, bHLH35, and ICE1. Here, we developed an algorithm, TransDetect, able to predict TF combinations controlling the expression level of a given gene. ![]() The accuracy of current methods at genome scale significantly drops with the increase in number of genes, which limits their applicability to more complex genomes, like animals and plants. Identifying transcription factor ( TFs) cooperation controlling target gene expression is still an arduous challenge.
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